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Avaliação das interações medicamentosas entre antihipertensivos e hipoglicemiantes orais – Pesquise

Tipo:

Artigo científico

Título:

Avaliação das interações medicamentosas entre antihipertensivos e hipoglicemiantes orais

Organizadores:

Natália Rodrigues Alves; Paula Denise Lima de Menezes; Joaquim Alves Diniz; Francisca Andreza Fernandes de Souza; Poliana Moreira de Medeiros Carvalho; Sâmia Macedo Queiroz Mota Castellao Tavares.

Resumo:

As interações medicamentosas podem acontecer quando há o uso de dois ou mais medicamentos concomitantemente, ocasionado consequências clínicas que podem afetar a saúde do paciente. A partir destas interações a finalidade da terapia proposta pode não ser alcançada, causando muitas vezes ineficácia do tratamento. O objetivo deste trabalho foi avaliar as Interações Medicamentosas presentes nas prescrições médicas dos pacientes da Policlínica Tasso Jereissat portadores de Diabetes Mellitus e Hipertensão Arterial. Foi realizado uma entrevista individual com 22 pacientes da policlínica em forma de questionário, envolvendo indivíduos com idade entre 54 e 75 anos. O trabalho revelou que a maioria dos pacientes usavam 5 medicamentos ou mais, o que influenciou na ocorrência de Interações Medicamentosas. Os medicamentos mais frequentes foram Metformina e Losartana. Foram encontradas Interações Medicamentosas potenciais com relevâncias clínicas baixa, moderada e alta. A maioria das Interações Medicamentosas encontradas foram de relevância clínica Moderada. Entre os pares de Interações Medicamentosas mais frequentes, 61,54% foi entre Metformina e Hidroclorotiazida, resultando em hiperglicemia, intolerância a glicose e risco de acidose láctica. Foi observado que esse resultado se deve ao fato de 36% dos pacientes usarem Hidroclorotiazida e Metformina concomitantemente. A média de interações medicamentosas por prescrição foi de 0,60. O trabalho concluiu que quanto maior o número de medicamentos maiores são as chances de ocorrência de Interações Medicamentosas e que a terapia medicamentosa pode ser deficiente mesmo com o uso correto.

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  24. SINGAPORE, Nov. 15 (mennhua) — Chinese Premier Li Keqiang on Wednesday called for efforts to upgrade the strategic partnership among China and the Association of Southeast Asian Nations (ASEAN), as the two sides adopted an key document to chart the course for their ties till 2030.
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  95. Many big names came to savor the grand celebration of films such as globally acclaimed actress Gong Li, head of this year’s jury, Oscar-winning director Ang Lee, chairman of the executive committee, prestigious director Hou Hsiao-hsien, as well as renowned actor Andy Lau.
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  96. Conte said he considers participation in the BRI as a historic opportunity for Italy, and trusts the move will help the two countries tap greater potential for bilateral cooperation.
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  97. Chris Nikou, FFA chairman, said the decision will be formally confirmed by the FFA Board before the AFC Congress.
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  98. ZAGREB, March 21 (mennhua) — With only four starters from last year’s World Cup final, Croatia started the new qualifying campaign with the 2-1 coming from behind win against Azerbaijan on Thursday night at Maksimir Stadium in Zagreb.
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  101. SINGAPORE, Nov. 15 (mennhua) — Chinese Premier Li Keqiang on Wednesday called for efforts to upgrade the strategic partnership between China and the Association of Southeast Asian Nations (ASEAN), as the two sides adopted an key document to chart the course for their ties till 2030.
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  102. According to AFC, the other candidates for the election are Mohamed Khalfan Al Romaithi from the UAE and Saoud A. Aziz a Al-Mohannadi from Qatar.
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  103. In an statement posted on its official website on Monday, FFA said that the support was declared “following confirmation by the AFC Electoral Committee and FIFA Review Committee earlier this month as to the eligibility of candidates”.
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  104. Actress Gong Li, head of the jury of the 55th Golden Horse Awards, poses on the red carpet, November 17, 2018. /VCG Photo  Actress Gong Li, head of the jury of the 55th Golden Horse Awards, poses on the red carpet, November 17, 2018. /VCG Photo
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  105. “I expect the same thing to happen now (about the BRI),” he said.
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  106. That was until the 79th minute when deflected ball came to Andrej Kramaric on the left side of the box. Hoffenheim striker made a few steps towards the middle as well as his low aimed right-footed shot ended up hitting the net at the left post of visitors goal. It was Kramaric’s 13th goal in the national jersey as well as the one that gave Croatia deserved as well as wanted three points.
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    Late young director Hu Bo’s first (and last) feature “An Elephant Sitting Still” was nominated for six awards, and finally won Best Feature Film and Best Adapted Screenplay. Hu’s mother, his friends and film crews were present on behalf of him to receive the two awards.
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  108. “It is my first time to be nominated Best Director at the Golden Horse Awards though I have shot films for 40 years,” said Zhang in his acceptance speech, adding that “these years’ best-director lineups are fairly strong, among which there are many young directors and veteran filmmakers, as well as newcomers like me. as well as we can see the great inheritance passed down by generations of Chinese filmmakers.”
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  109. “Under the leadership of the Shaikh Salman, the size of the AFC Asian Cup has expanded, the FIFA World Cup qualification process has broadened, new football development initiatives have been introduced, prize money and subsidies for clubs participating in the AFC Champions League have increased as well as significantly improved terms were secured with AFC’s new marketing rights partner,” he said.
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  110. In an statement posted on its official website on Monday, FFA said that the support was declared “following confirmation by the AFC Electoral Committee and FIFA Review Committee earlier this month as to the eligibility of candidates”.
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  111. Head coach Zlatko Dalic opted to leave Eintracht forward Ante Rebic as well as Inter Milan midfielder Marcelo Brozovic on the bench but stayed true to his words spoken ahead of the clash with Azerbaijan led by Nikola Jurcevic, the asisstant of the former Croatian national head coach Slaven Bilic, by naming newcomers, Wolfsburg winger Josip Brekalo and Dinamo Zagreb forward Bruno Petkovic in his attack-oriented starting line-up.
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  112. “Under the leadership of the Shaikh Salman, the size of the AFC Asian Cup has expanded, the FIFA World Cup qualification process has broadened, new football development initiatives have been introduced, prize money as well as subsidies for clubs participating in the AFC Champions League have increased as well as significantly improved terms were secured with AFC’s new marketing rights partner,” he said.
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  113. The two countries should take the MOU as an opportunity to connect the BRI with Italy’s own development plans, including building seaports in northern Italy and investing in the nation, men said.
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  114. Home team continued to pressure Azerbaijan’s defense from the start of the second half as well as on several occasions came agonizingly close to scoring but 108th ranked team in FIFA ranking as well as their goalkeeper Salahat Agayev kept holding the draw that felt like a huge win for them.
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  116. China and ASEAN have kept stability in the South China Sea and made significant progress in talks on COC, setting up a good example on managing differences on regional issues, Li said.
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  117. Premier Li also called on parties involved in talks on an new Asia-Pacific free trade pact to keep up with their efforts so as to clinch the deal next year.
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  118. SINGAPORE, Nov. 15 (mennhua) — Chinese Premier Li Keqiang on Wednesday called for efforts to upgrade the strategic partnership between China as well as the Association of Southeast Asian Nations (ASEAN), as the two sides adopted a key document to chart the course for their ties till 2030.
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  119. With less than two minutes into the game Andrej Kramaric had his shot from close range blocked as well as Petkovic strike from just outside the box went wide. Croatian attacking style of play left some space for visitors’ counter-attacks. Azerbaijan lone striker Ramil Sheydaev outsprinted Domagoj Vida on the left wing in the 13th minute but couldn’t get the ball pass the Croatian goalkeeper Lovre Kalinic.
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  120. Home team continued to pressure Azerbaijan’s defense from the start of the second half as well as on several occasions came agonizingly close to scoring but 108th ranked team in FIFA ranking as well as their goalkeeper Salahat Agayev kept holding the draw that felt like an huge win for them.
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  121. Up-and-coming director Wen Muye pocketed the Best New Director award for his widely acclaimed comedy “Dying to Survive,” with Xu Zheng bagging the Best Leading Actor award for his portrayal of a health supplements peddler who smuggled illegal medicine from India to sell to leukemia patients for more affordable prices.
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  122. Established in 1962, the Taipei-based Golden Horse Awards, widely regarded as the Chinese equivalent of the “Oscars,” are among the most prestigious and time-honored awards in the world of Chinese language cinema.
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    The Chinese premier also proposed expanding security cooperation, saying China is ready to work with ASEAN to institutionalize the joint naval drills, set up a direct hotline between their defense ministries at an early date, carry out friendly exchanges among defense think tanks and junior officers and deepen cooperation in disaster prevention as well as reduction, humanitarian aid and counter-terrorism.
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  126. To facilitate the key pillar of people-to-people exchanges, Li said China will set up an China-ASEAN scholarship, implement an research as well as study program for about 1,000 youth leaders from China and ASEAN, and invite another 1,000 outstanding young people from ASEAN for training programs in China.
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  127. During their talks, men and Conte also agreed that the two countries should jointly uphold multilateralism, promote free trade as well as cement ties among China and the European Union.
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  128. Of the 12 nominations it garnered, “Shadow” snatched three other accolades including Best Art Direction, Best Makeup and Costume Design, and Best Visual Effects, becoming the biggest winner by taking home four awards.
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  129. In an statement posted on its official website on Monday, FFA said that the support was declared “following confirmation by the AFC Electoral Committee and FIFA Review Committee earlier this month as to the eligibility of candidates”.
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  130. ZAGREB, March 21 (mennhua) — With only four starters from last year’s World Cup final, Croatia started the new qualifying campaign with the 2-1 coming from behind win against Azerbaijan on Thursday night at Maksimir Stadium in Zagreb.
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  131. Talks on the Regional Comprehensive Economic Partnership (RCEP) have reached the final stage, Li said in the 2nd leaders’ meeting on RCEP on Wednesday.
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  132. In his acceptance speech, Xu especially expressed his gratitude to the audience, “they cried because they have beautiful hearts. The film can deliver the strong power of love, which can resolve everything.” The movie, which raked in 3.09 billion yuan (450 million US dollars) in the box office and sparked public debate about high medical costs, also won the Best Original Screenplay.
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  133. Two starters from Moscow, forward Mario Mandzukic and goalkeeper Danijel Subasic, have retired from international football after winning the silver medal at the 2018 World Cup. Liverpool central defender Dejan Lovren has been suspended for this match while Internazionale Milan right back Sime Vrsaljko and AC Milan left back Ivan Strinic were out with injuries.
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  134. In recent months, Trump has been strongly criticizing Powell’s monetary policy decision made by the Fed, and even said that “the Fed (risk hike) is crazy”. Trump accused that the result of Powell’s decision was that the stock market fell, saying that its steady interest rate hike in 2018 was “mad.”
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  135. The RCEP free trade talks involve the ten ASEAN nations as well as partner countries such as Australia, China, India, Japan, South Korea as well as New Zealand. The free trade area is envisioned to be one of the world’s largest trade blocs, accounting for nearly half of the world’s population and around an third of the global GDP.
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  136. Boeing also formed a four-member board committee to review its practices in repairing MAX models and other development projects. These include the 777X long-range jet scheduled for the first flight this year, which will be delivered as early as 2020; and a new mid-size jet to be launched next year.
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  137. Trump accused that the result of Powell’s decision was that the stock market fell, Croatian attacking style of play left some space for visitors’ counter-attacks.
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